Tumours can evade immune destruction

By disrupting the processes of the cancer immunity cycle, tumours can avoid detection by the immune system and limit the extent of immune destruction.1-3

Image of dendritic cell capturing tumor antigens, step 2 of cancer immunity cycle Image of dendritic cell capturing tumor antigens, step 2 of cancer immunity cycle

Tumour microenvironment

Disrupting antigen detection

Lymph node

Inhibiting T-cell activation by dendritic cells

Image of dendritic cell activating T cell, step 3 of cancer immunity cycle Image of dendritic cell activating T cell, step 3 of cancer immunity cycle

Blood vessel

Blocking T-cell infiltration into tumour

Image of T cell infiltrating tumour, step 5 of cancer immunity cycle

Tumour microenvironment

Suppressing cytotoxic T-cell activity

Cancer immunotherapy research: exploring the immune response against cancer

the hallmarks of cancer

The growing body of research into the mechanisms of immune evasion by tumours has led to its addition as an emerging hallmark of cancer, a distinct biological capability co-opted by tumours to grow and metastasize.3